Risk Factors of Cholangiocarcinogenesis in Parasitization of a Natural Focal Ecopathogen Helminth <i>Opisthorchis felineus</i>

Epidemiological researches, carried out by professor A.A. Shain in Ob-Irtysh basin of Tyumen region, have allowed to consider chronic opisthorchiasis as facultative liver precancer and develop the original concept cholangiocarcinogenesis on background long-term invasion trematode Opisthorchis felineus hepatobiliary system body. According this concept, initiating role cholangiocyte transformation belongs endogenous factors secondary bile acids, having mutagenic/carcinogenic properties, which formation is mediated helminthosis-related exogenous intestinal microflora intrahepatic ducts. Obtained data confirmed content carcinogenic acids duct opistorchosis patients. Cholestasis, caused parasitization helminth body, mediates host promoter factors, contributing cholangiocarcinoma progression. These include: high concentration products helminths activity lipid peroxidation somatic cell membranes. Promoter cholangiocanerogenesis are also disorders membranes structure, tissue regulation their regeneration, DNA repair anti-tumorigenic protection The results study confirm occurrence development process infestation, proposed Professor allow reasonably approaches correction homeostasis systems organism specified helminthiasis. Which determines prevention malignant ductal epithelium posthelminthic period.